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KMID : 0648320090150030018
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Journal of The Korean Society of Hypertension
2009 Volume.15 No. 3 p.18 ~ p.27
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Metabolic Syndrome and Target Organ Damage in Untreated and Treated Hypertensive Patients : Korean Multicenter Registry
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Kim Young-Kwon
Lee Hae-Young
Cho Eun-Ju
Rim Se-Joong
Park Jeong-Bae
Han Kyoo-Rok
Hyon Min-Su
Kim Cheol-Ho
Jun Jae-Eun
Hong Soon-Pyo
Choi Young-Jin
Ahn Kyoung-Ju
Choi Su-Yeon
Kim Dong-Woon
Kim Sang-Hyun
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Abstract
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Background: The metabolic syndrome (MS) is associated with increased hypertension-related target organ damage. We analyzed the prevalence and the relationship between the MS and cardio-renal changes in a large number of hypertensive patients.
Methods: Three hundred and seventy seven untreated and 677 treated patients without cardiovascular disease, alleged diabetes, and medication for dyslipidemia were enrolled. Albuminuria was measured by a spot urine albumin-to-creatinine ratio. Left ventricular hypertrophy (LVH) was assessed by an ECG.
Results: The prevalence of MS was higher in the treated patients than in the untreated patients (60.0 vs. 50.4%, p=0.003). The treated patients had a higher number of the MS components, except for hypertension, than the untreated patients (1.8±1.1 vs. 1.6±1.2, p=0.001). In the untreated patients, the prevalence of an increased serum creatinine (s-Cr) or low eGFR was similar to those with or without the MS (2.6 vs. 5.4%, p=NS). The prevalence of microalbuminuria (MA) and clinical albuminuria (CA) was also similar (MA, 21.6 vs. 16.4%; CA, 4.0 vs. 2.3%; both, p=NS). In the treated patients, however, those with the MS showed a higher prevalence of increased s-Cr or low eGFR (11.9 vs. 4.8%, p<0.01) and the MA (19.5 vs. 9.0%, p<0.001) than those without the MS. The prevalence of CA was not different (1.6 vs. 1.6%, p=NS). The prevalence of LVH was increased when the MS was present in untreated patients (6.1 vs. 1.7%, p<0.05), while it was similar in the treated patients (3.0 vs. 2.6%, p=NS).
Conclusion: The impact of the MS on renal changes was more noticeable in treated patients, while the impact of the MS on LVH was more noticeable in untreated patients.
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KEYWORD
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hypertension, metabolic syndrome, target organ damage
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